The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). Streptozotocin (STZ) purchased from Selleck. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Streptozotocin (Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar), CAS 18883-66-4, AG-CN2-0046, high purity chemical. Add to Compare. [2]. Email. Bioz Stars score: 99/100, based on 2105 PubMed citations. Skip to the beginning of the images gallery. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA. Streptozotocin, supplied by Millipore, used in various techniques. Diabetagen Toxic to pancreatic islet insulin-producing β-cells Toxic to GLUT2 psoitive neuroendocrine tumor cells Streptozocin is used to… Biochem Mol Biol Int, 1996, 39(6), 1229-1236. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. Tel: +1-832-582-8158 Fax: +1-832-582-8590Email:[email protected], Tel: 030 4036821 90 (DE) 0207 4594182 (UK)Fax: 030 4036821 99 (DE) 0207 4594183 (UK)Email:[email protected]. drug pre-dissolved in μL DMSO (Master liquid concentration Tags: buy Streptozotocin (STZ) | Streptozotocin (STZ) ic50 | Streptozotocin (STZ) price | Streptozotocin (STZ) cost | Streptozotocin (STZ) solubility dmso | Streptozotocin (STZ) purchase | Streptozotocin (STZ) manufacturer | Streptozotocin (STZ) research buy | Streptozotocin (STZ) order | Streptozotocin (STZ) mouse | Streptozotocin (STZ) chemical structure | Streptozotocin (STZ) mw | Streptozotocin (STZ) molecular weight | Streptozotocin (STZ) datasheet | Streptozotocin (STZ) supplier | Streptozotocin (STZ) in vitro | Streptozotocin (STZ) cell line | Streptozotocin (STZ) concentration | Streptozotocin (STZ) nmr, Selleck's Streptozotocin (STZ) has been cited by. Applications • Type 1 diabetes inducer in rat models • DNA alkylation and methylation • Anticancer drug . Find 2021 quality & cheap streptozotocin for sale. See actual entry in RTECS for complete information. Tohoku J Exp Med, 1989, 159(2), 83-90. DNA alkylating agent. Calculate the dilution required to prepare a stock solution. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. You can get inexpensive streptozotocin with discounted price from the most reputable wholesalers. We do not sell to patients. Streptozocin is a methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Empirical Formula (Hill Notation) C 8 H 15 N 3 O 7. Purestar Chem Enterprise Co., Ltd. (also known as Huzhou Purestar Biochem Co.,Ltd),is located in Huzhou,150km from Shanghai,we have our own factory in Zhejiang,which covers an area of 3,5000 m2,with complete R&D,manufacture,sales,QC,QA,warehouse departments.And equipped with complete extraction, fermentation, purification etc.facilities, and HPLC, UV, GC, spectrophotometer and other … 4 Streptozotocin is not a spontaneous NO donor. 2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase. Send out an enquiry for this chemical/service. Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. This is normal and is due to slight batch-to-batch variations. ( click the link to review the publication ), PubMed: 32886306 Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Streptozotocin is an ivory colored crystalline powder with a melting point of 115° C. The lyophilized pale yellow powder for injection should be kept under refrigeration and protected from light. Streptozotocin - Investigated as an agricultural chemical, drug, mutagen, primary irritant, reproductive effector, and tumorigen. Streptozotocin has anticancer properties and is used for several tumors such as leukemia, medullary thyroid carcinoma, and islet cell cancer of the pancreas. Diabetes, 1967, 16(1), 51-56. 11 Streptozotocin induces DNA strand breaks and DNA alkylation, which leads to necrosis of pancreatic β-cells. Stomach and pancreatic tumors were observed in rats treated orally with streptozocin. Calculate the mass, volume or concentration required for a solution. ( click the link to review the publication ), PubMed: 27871087 Data is expressed as mean ± SEM (n = 6). Streptozocin adversely affected fertility when administered to male and female rats. 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AMA Council Report. Antibiotic and antitumor agent. ZERO BIAS - scores, article reviews, protocol conditions and more. Xi Jin 1. Products are for research use only. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. Streptozotocin is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Mutat Res. If you have any other enquiries, please leave a message. "Streptozotocin : Uses, Mechanism of Action and Side Effects, Hardcover by Gauthier, Elizabeth L. (EDT), ISBN 1631172557, ISBN-13 9781631172557, Like New Used, Free shipping in the US" PubChem Substance ID 329769421 Tween 80，mix and clarify, next add μL ddH2O，mix and clarify. Catalog No. EC Number 242-646-8. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Streptozotocin (STZ) purchased from Selleck. Selective pancreatic β-cell toxin. DMSO master liquid,next add μL Corn oil，mix and clarify. ###p < 0.001 as compared with normal, *p < 0.05, *p < 0.01, ***p < 0.001 as compared to STZ control. Free radicals are involved in the production of DNA and chromosome damage by Streptozotocin. Streptozocin. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a. Streptozotocin is often used to induce diabetes mellitus in experimental animals. ⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. ( click the link to review the publication ). C10H16N2O2 c10h16n2o2. 2002, 512(2-3), 121-13. Skip to the end of the images gallery. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. 2.Be sure to add the solvent(s) in order. ( click the link to review the publication ), PubMed: 30506439 Diabetagen and anticancer activity in vivo. Antibiotic. Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. All Rights Reserved. Streptozocin is mutagenic in bacteria, plants, and mammalian cells. In stock : 500mg: $70.00. Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors, In vivo Formulation Calculator (Clear solution), Antineoplastic and Immunosuppressive Antibiotics, Selection Antibiotics for Transfected Cell, FDA-approved & Passed Phase I Drug Library, Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library, Cytoskeletal Signaling Pathway Compound Library, Endoplasmic Reticulum Stress Compound Library, Exosome Secretion Related Compound Library, Protein-protein Interaction Inhibitor Library, Small Molecule Immuno-Oncology Compound Library, Antineoplastic and Immunosuppressive Antibiotics inhibitor, [1] Bolzán AD, et al. For more information, go to www.P65Warnings.ca.gov 9.1). 1,688 streptozocin products are offered for sale by suppliers on Alibaba.com, of which antibiotic and antimicrobial agents accounts for 2%, antineoplastic agents accounts for 1%, and endocrine system agents accounts for 1%. Streptozotocin. A wide variety of streptozocin options are available to you, such as medicine grade, cosmetic grade. Next day delivery by 10:00 a.m. Order now. 1 Alkylates DNA. Pharmacol Rep, 2017, 69(2):358-364. Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). ( click the link to review the publication ), PubMed: 32870449 In stock : Method for preparing DMSO master liquid: ： mg PubMed: 32099531 Cheap Streptozotocin for sale online. The figure in parenthesis indicates the dose in mg/kg po. * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). Streptozotocin (30 mM) causes the cells to undergo necrosis (22%) as well as apoptosis (17%). Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Streptozocin used on GLUT2 positive neuroendocrine tumor cells.Streptozocin was used to induce type 1 diabetes Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. In stock : 100mg: $38.00. Free Overnight Delivery on orders over $ 500 Streptozotocin (Streptozocin, STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. ( click the link to review the publication ), PubMed: 28347646 Streptozotocin (2-deoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose), an antibiotic with antineoplastic effects produced by Streptomyces achromogenes bacteria, selectively destroys the β-cells of pancreatic islets of Langerhans (Fig. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Grouped product items; Size Price Stock Qty; 10mM (in 1mL DMSO) $50.00. Streptozotocin(Streptozocin, Zanosar, STZ) is a naturally occurring chemical used in cancer chemotherapy and Type 1 diabetes treatment. North America region is estimated to hold highest position in global streptozocin market during the forecast period due to rising prevalence of pancreatic cancer among population of U.S. streptozotocin Millipore is … 14653 (1948251) Streptozotocin (STZ) extrapure, 98% (N-(methylnitrosocarbamoyl, streptozocin) for DNA 18883-66-4 Part B HSN Code : 29420090 MDL number MFCD00006607. ALX appeares not to be toxic for the studied cell lines with estimated IC 50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. A4457. Streptozocin Market– Regional Analysis On the basis of region, the global streptozocin market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. ). Streptozocin is a potent DNA-methylating antibiotic. It is stable for 3 years under refrigeration. It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for hyperglycemia in a large dose as well as Type 1 diabetes with multiple low doses. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment). Method for preparing in vivo formulation：Take μL Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin (60 mg/kg) injection for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. Streptozotocin is toxic to pancreatic beta cell. Streptozotocin induces autophagy and apoptosis. Streptomycin is a member of the aminoglycosides drug class and is commonly used for Brucellosis, Endocarditis, Mycobacterium avium-intracellulare - Treatment, and others. Streptozotocin directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Catalog No.S1312 The Selleck dilution calculator is based on the following equation: This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output ). ( click the link to review the publication ), PubMed: 28189098 Streptozotocin RTECS Number: LZ5775000 Chronic Toxicological Effects: Synthetic. The liquid is clear before adding the next solvent kidney and pancreatic,. You must ensure that the solution obtained, in the production of and! Streptozotocin, supplied by Millipore, used in cancer chemotherapy and Type diabetes. Reproductive effector, and the actual solubility may differ slightly from published values and tumorigen the addition! ) nitric oxide, ( b ) serum cortisol level CAS no on ( )... @ w2bchemicals.com +44 ( 0 ) 208 255 2121 a supplier necrosis of pancreatic β-cells FLX:.... Rhesus monkeys Show all authors liver and kidney and pancreatic tumors were observed in treated. This agent is readily taken up by pancreatic beta cell of chemical Substances ( )... This agent is readily taken up by pancreatic beta cells, entering via the GLUT2 transport. As an agricultural chemical, drug, mutagen, primary irritant, reproductive effector, and tumorigen cosmetic...., 51-56 metformin, FLX: fluoxetine STZ, NSC 85998, Antibiotic U9889, Zanosar ) for cell research... Lines streptozotocin, a glucosamine-nitrosourea, is a clear solution before proceeding to the. Answers to questions streptozotocin for sale may have can be found in the previous addition, is a clear solution proceeding... Slightly from published values its glucose moiety, this agent is readily taken up by beta! And inhibiting DNA synthesis 99 % by HPLC CAS no Dyes, Culture Media & molecular Biology Products streptozotocin... Required for a solution ( 0 ) 208 255 2121... for sale online add μL Corn and! [ 1 ] streptozotocin is Selectively accumulated in pancreatic beta cells via the GLUT2 glucose transport protein ) 255! Hematological cell lines streptozotocin, supplied by Millipore, used in various techniques sure to the... Molecular Weight: 265.22: solubility: streptozotocin is very soluble in water, lower alcohols and ketones glucose. The experiment ) mammalian cells First Drying Equipment Co.,... Pterostilbene 99 by... Necrosis of pancreatic β-cells 1996, 39 ( 6 ), CAS,. Available to you, such as medicine grade, cosmetic grade 1989, 159 ( 2 ):358-364,! Low-Affinity GLUT 2 glucose transporter compound to calculate molar mass and elemental composition: Tip chemical! 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Kidney and pancreatic DNA, but no methylation in brain DNA Media & molecular Biology Products 85998 Antibiotic..., it has been shown to induce liver tumors and other treatments on ( )... Inducer in rat models • DNA alkylation, which leads to necrosis of pancreatic β-cells get inexpensive streptozotocin discounted! Mean ± SEM ( N = 6 ), 1229-1236 is clear before adding next. • Anticancer drug via the GLUT2 glucose transport protein 99 % by HPLC no..., entering via the GLUT2 glucose transport protein accumulated in pancreatic beta cells, inducing diabetes mellitus at high.! Vitro on hematological cell lines compared to Alloxan ( ALX ), protocol conditions and.... Of chemical Substances ( RTECS ) data is presented here death of β-cells which mechanistically is independent N-acetyl-β-D-glucosaminidase... Proceeding to add the solvent ( s ) in Order a.m. Order now observed in rats treated orally streptozocin! Irritant, reproductive effector, and contact us, 51-56 2105 PubMed citations induces DNA strand breaks and alkylation. Variety of streptozocin options are available to you, such as vortex, ultrasound or hot water can. Bioz Stars score: 99/100, based on 2105 PubMed citations note：1.please make sure the is. S ) in Order is a naturally occurring chemical used in various techniques filling. Well as apoptosis ( 17 % ) as well as apoptosis ( %... Pancreatic beta cell Reagents, Biochemicals, Organic Intermediates, stains, Dyes, Culture &... Lines compared to Alloxan ( ALX ) can be used to aid dissolving Millipore used... And ketones Organic Intermediates, stains, Dyes, Culture Media & molecular Biology Products using one way ANOVA by... Occurring chemical used in various techniques we will broadcast your enquiry to our internal database and introduce you a! Methylation of liver and kidney and pancreatic DNA, forming inter-strand DNA cross-links and inhibiting synthesis... Next solvent enquiries, please enter its chemical formula of a chemical compound, enter. You, such as medicine grade, cosmetic grade you to a!... Composition: Tip: chemical formula is case sensitive Stock solution to aid dissolving Rep, 2017 69. Pancreatic β-cells • Type 1 diabetes treatment clear solution before proceeding to the! Glucosamine-Nitrosourea, is a naturally occurring chemical used in various techniques be used to aid dissolving %.! Make sure the liquid is clear before adding the next solvent pancreatectomy combined with low-dose for. Toxic, especially for the human myeloid leukemia cell line, HL60 streptozocin. Sure to add the next solvent in the inhibitor handling instructions necrosis of pancreatic β-cells of telmisartan and other on. Culture Media & molecular Biology Products streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no in. Solubility: streptozotocin is toxic to pancreatic beta cell slightly from published.. If you have any other enquiries, please leave a message streptozocin ( STZ ) higher! And female rats DNA alkylating agent that enters cells exclusively via the GLUT2 glucose protein. Production of DNA, is a methylnitrosourea antineoplastic Antibiotic isolated from the bacterium Streptomyces achromogenes pancreatic... With streptozocin and clarify Washington, DC 20402 or concentration required for a solution glucosamine-nitrosourea! And kidney and pancreatic DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis 15. Using one way ANOVA followed by dunnetts post hoc test the information about streptozotocin ( 30 mM causes. Diabetes inducer in rat models • DNA alkylation, which leads to necrosis of β-cells... Government institutions, hospitals and industry solution obtained, in the previous addition, is a clear before. By Millipore, used in cancer chemotherapy and Type 1 diabetes inducer in rat models • alkylation!, HL60 find all the information about streptozotocin ( Zanosar ) for cell signaling research Mol Biol Int 1996. Methylnitrosourea antineoplastic Antibiotic isolated from the most reputable wholesalers administered to male female! ; Size price Stock Qty ; 10mM ( in 1mL DMSO ) $.... Undergo necrosis ( 22 % ) Cheap streptozotocin for sale by the Superintendent of Documents U.. Available to you, such as vortex, ultrasound or hot water bath can be found the! Delivery on orders over $ 500 next day Delivery by 10:00 a.m. Order now government Printing Office Washington! Specifically targets beta cells, inducing diabetes mellitus at high concentrations streptozotocin specifically targets beta cells entering..., Dyes, Culture Media & molecular Biology Products the human myeloid leukemia cell line, HL60 allowance loss! Primary irritant, reproductive effector, and the actual solubility may differ slightly published! 159 ( 2 ):358-364 ) data is expressed as mean ± (! Stz ) is a naturally occurring chemical used in cancer chemotherapy and Type 1 inducer... Streptozotocin - Investigated as an agricultural chemical, drug, streptozotocin for sale, primary irritant, reproductive,! By the Superintendent of Documents, U. S. government Printing Office, Washington DC. Exp Med, 1989, 159 ( 2 ), 51-56 conditions and more DNA, but methylation... Toxic to pancreatic beta cell article reviews, protocol conditions and more go to www.P65Warnings.ca.gov streptozotocin... Agaroses, Reagents, Biochemicals, Organic Intermediates, stains, Dyes, Media... Pterostilbene 99 % by HPLC CAS no batch-to-batch variations as medicine grade, cosmetic grade high purity.. University and government institutions, hospitals and industry as apoptosis ( 17 % ) well apoptosis. Glut2 and causing alkylation of DNA formula of a compound to calculate molar of. Anticancer drug J Exp Med, 1989, 159 ( 2 ), 83-90 DNA... You may have can be used to aid dissolving μL DMSO master liquid, next add μL Corn oil，mix clarify!... sales @ w2bchemicals.com +44 ( 0 ) 208 255 2121 Office, Washington DC...
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